SUFENTANIL CITRATE Property

Melting point:

96.60C

Flash point:

9℃

storage temp. 

-20°C Freezer

solubility 

H2O: soluble1mg/mL, clear

form 

powder

color 

white to beige

Stability:

Hygroscopic

Safety

Hazard Codes 

T+,T,F

Risk Statements 

26/27/28-39/23/24/25-23/24/25-11

Safety Statements 

26-27-28-36/37/39-45-36/37-16-7

RIDADR 

3249

WGK Germany 

3

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

2934910000

Toxicity

LD50 intravenous in dog: 14100ug/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

SUFENTANIL CITRATE Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Uses

Potent derivative of Fentanyl. Analgesic (narcotic). Controlled substance (opiate)

Definition

ChEBI: Sufentanil citrate is an anilide.

brand name

Sufenta (Akorn).

General Description

Sufentanil is a short acting synthetic opioid analgesic most commonly used for pain relief during medical operations. This certified solution standard is applicable to use in clinical toxicology, pain prescription monitoring, or forensic analysis by LC-MS/MS or GC/MS. Sufentanil is sold under the trade name Sufenta.

Clinical Use

Addition of the 4-methoxymethyl group and bioisosteric replacement of the phenyl with a 2-thiophenyl on the fentanyl structure results in a 10-fold increase in μ opioid activity. The resultant compound, sufentanil, is 600 to 800 times more potent than morphine. Despite its greater sedative and analgesic potency, sufentanil produces less respiratory depression at effective anesthetic doses. Sufentanil is available in an intravenous dosage form, and it is used for anesthetic procedures. It has a faster onset and shorter duration of action than fentanyl. The short duration is caused by redistribution from brain tissues after intravenous dosage.

Veterinary Drugs and Treatments

An opioid analgesic, sufentanil may be useful as an anesthesia adjunct or as an epidural analgesic. In humans, it has been used as the primary anesthetic in intubated patients with assisted ventilation, and as a post-operative analgesic.